Korean J Ophthalmol > Volume 7(2); 1993 > Article
Korean Journal of Ophthalmology 1993;7(2):65-69.
DOI: https://doi.org/10.3341/kjo.1993.7.2.65    Published online December 30, 1993.
Silicone oil keratopathy.
Woo Chul Choi, Sang Kyung Choi, Jin Hak Lee
1Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
2Department of Ophthalmology, Seoul Red Cross Hospital, Seoul, Korea.
Light microscopy and electron microscopic examination were carried out on the corneal buttons of two patients who required penetrating keratoplasty for treatment of corneal complication following the intraocular injection of silicone oil to repair recurrent retinal detachments in aphakic eyes. Light microscopic examination demonstrated increased cellularity and irregularity of collagen fibers of stromal layer, defect of endothelial cell layer and endothelial degeneration. Electron microscopy examination demonstrated marked decrease in endothelial cell population density, accompanied by flattening and thinning of the remaining cells and attenuation of cell borders. There were silicone droplets in the endothelial cell layer and collagenous layer posterior to endothelial layer. These findings are well correlated to clinical manifestation and are thought to be rather due to barrier effect of silicone oil than direct toxicity.
Key Words: silicone oil;keratopathy;histopathology

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