Korean J Ophthalmol > Volume 9(1); 1995 > Article
Korean Journal of Ophthalmology 1995;9(1):51-58.
DOI: https://doi.org/10.3341/kjo.1995.9.1.51    Published online June 30, 1995.
Effects of mitomycin C on delayed adjustment in experimental strabismus surgery.
Se Oh Oh, Bong Leen Chang, Jaeheung Lee
1Department of Ophthalmology, College of Medicine, Chungbuk National University, Cheongju, Korea.
2Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
In adjustable strabismus surgery, a satisfactory final result would be achieved with delayed adjustment. However, the postoperative adhesions following strabismus surgery make delayed adjustment impossible. We evaluated the efficacy of mitomycin C in reducing the severity of postoperative adhesions following strabismus surgery and in delaying the time adjustment after surgery. Experimental rabbits underwent a hang-back recession procedure in the superior rectus muscle. A topical application of mitomycin C was made between the conjunctiva and the sclera for 5 minutes during the operation. We then studied the possible time of delayed adjustment and estimated the minimal forces required for the adjustment. The topical application of 0.1 mg/ml mitomycin C between the conjunctiva and sclera allowed for a 2-week delayed adjustment after surgery, and 0.2 mg/ml mitomycin C prevented the adhesions between these tissues and the muscle 5 weeks after surgery. These results suggest that topical mitomycin C may enhance the success rate of strabismus surgery with delayed adjustment and reduce postoperative adhesions.
Key Words: adjustable strabismus surgery;delayed adjustment;postoperative adhesions;mtomycin C

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