Korean J Ophthalmol > Volume 10(2); 1996 > Article
Korean Journal of Ophthalmology 1996;10(2):122-123.
DOI: https://doi.org/10.3341/kjo.1996.10.2.122    Published online December 30, 1996.
Carbon monoxide poisoning as an epigenetic factor for Leber's hereditary optic neuropathy.
Jeong Min Hwang, Hye Won Park
1Department of Ophthalmology, Seoul City Boramae Hospital, Seoul, Korea.
2Department of Pediatrics, Seoul City Boramae Hospital, Seoul, Korea.
Abstract
A 45-year-old Korean woman visited our hospital complaining of poor vision after carbon monoxide (CO) poisoning. We have confirmed the presence of a point mutation at position 11778 in the ND4 gene of mitochondrial DNA. This case suggests that CO poisoning may precipitate the clinical expression of Leber's hereditary optic neuropathy (LHON). To our knowledge, this would be the first case report of clinical expression of LHON precipitated by CO poisoning.
Key Words: carbon monoxide (CO) poisoning;Leber's hereditary optic neuropathy (LHON)
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