An unusual type of cancer-associated retinopathy in a patient with ovarian  cancer.

Yoon,  Y H; Cho,  E H; Sohn,  J; Thirkill,  C E

doi:1999.13.1.43

Korean J Ophthalmol > Volume 13(1); 1999 > Article

Research Support, U.S. Gov't, P.H.S.

Korean Journal of Ophthalmology 1999;13(1):43-48.
DOI: https://doi.org/10.3341/kjo.1999.13.1.43 Published online June 30, 1999.

An unusual type of cancer-associated retinopathy in a patient with ovarian cancer.

Y H Yoon, E H Cho, J Sohn, C E Thirkill

Department of Ophthalmology, College of Medicine, University of Ulsan, Seoul, Korea.

Abstract

We studied a case of unusual retinopathy in a 35-year-old woman who presented with bilateral visual deterioration due to retinal pigmentary mottling and serous elevation in the posterior pole. Two years before, she had undergone hysterectomy and bilateral salphingo-oophorectomy for ovarian cancer. Her electroretinogram became subnormal, and her fluorescein angiogram exhibited multiple deep retinal pigment epithelial leakages and subretinal dye pooling in both eyes. Corticosteroid therapy failed to prevent visual loss. She was found to possess antibodies against retinal 45 kd protein. This led to a diagnosis of cancer-associated retinopathy with atypical protein profile. We report a rare variety of cancer-associated retinopathy in a patient with-ovarian cancer.

Key Words: Cancer-associated retinopathy;Paraneoplastic syndrome;Autoantibody;Ovarian cancer