| Significance of chorioretinal atrophy using ultra-widefield reflectance image as a risk factor for myopic choroidal neovascularization |
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Wonyung Son1,2, Kyungmin Lee3, Sang Hyun Park3, Min Sagong1,4 |
1Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, South Korea
2Department of Ophthalmology, Soonchunhyang University Gumi Hospital, Gumi, South Korea
3Department of Robotic Engineering, DGIST, Daegu, South Korea
4Yeungnam Eye Center, Yeungnam University Hospital, Daegu, South Korea |
Correspondence:
Min Sagong, Tel: +82-53-620-3443, Fax: +82-53-626-5936,
Email: msagong@yu.ac.kr
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Received: 22 December 2025 • Revised: 8 May 2026 • Accepted: 26 June 2026 |
| Abstract |
Purpose
To evaluate whether increased ultra-widefield (UWF) red-separation reflectance and choroidal thinning are associated with myopic choroidal neovascularization (mCNV) in eyes with posterior staphyloma using a paired-eye design.
Methods
This retrospective paired-eye study included 35 patients who had both bilateral pathologic myopia and posterior staphyloma, with unilateral mCNV. Red-separation UWF images were used to measure the mean intensity of the posterior staphyloma (PS) and outer (O) areas, and the reflectance ratio (RR) was recalculated as PS/O. Choroidal thickness (CT), posterior staphyloma height, and coefficient α were measured on spectral-domain optical coherence tomography. Matched associations with mCNV were analyzed using conditional logistic regression stratified by patient.
Results
Eyes with mCNV had lower CT (44.91 ± 22.03 vs. 62.37 ± 28.66 μm; P <0.001) and higher RR (1.51 ± 0.25 vs. 1.32 ± 0.28; P <0.001) than fellow eyes. In the primary multivariable conditional logistic model, lower CT (per 10 μm: OR, 0.58; P = 0.042) and higher RR (per 0.1 unit: OR, 2.37; P = 0.026) were independently associated with mCNV. Discriminative performance was modest (AUC, 0.71 for CT and 0.67 for RR).
Conclusion
In this cross-sectional paired-eye study, lower CT and higher UWF reflectance within the posterior staphyloma were associated with the presence of mCNV. RR may be a useful adjunctive imaging marker, although its clinical discrimination was modest. |
| Key Words:
Choroidal neovascularization; degenerative myopia; optical imaging |
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