| Association between Skeletal Muscle Mass and Ocular Perfusion Pressure in Glaucoma |
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Jisoo Kang1, Ji Hong Kim1, Yu Jeong Kim1, Han Woong Lim1, Jooyoung Yoon2, Won June Lee1 |
1Department of Ophthalmology, Hanyang University Seoul Hospital, Hanyang University College of Medicine, Seoul, Korea
2Department of Ophthalmology, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, Korea |
Correspondence:
Jooyoung Yoon, Tel: 82-31-560-2166, Fax: 82-31-560-2170,
Email: jycyoon123@hanyang.ac.kr
Won June Lee, Tel: 82-2-2290-8570, Fax: 82-2-2291-8517,
Email: wonjunelee@hanyang.ac.kr
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Received: 19 February 2025 • Revised: 26 March 2025 • Accepted: 21 May 2025 |
| Abstract |
Purpose
This study aimed to investigate the relationship between body composition and glaucoma by analyzing the associations between anthropometric and ocular parameters.
Methods
A total of 494 eyes from 247 patients were reviewed from a general health examination database at a tertiary hospital. Anthropometric parameters were assessed using a multifrequency bioelectrical impedance device. Mean ocular perfusion pressure (MOPP) was calculated based on systolic and diastolic blood pressures and intraocular pressure (IOP). Retinal thickness and other ocular parameters were analyzed for their association with body composition.
Results
A total of 221 eyes from 221 patients, including 104 with glaucoma, were enrolled in the final analysis. The prevalence of sarcopenia was significantly higher in patients with glaucomatous damage than in those without (p = 0.025). Higher IOP showed significant associations with lower MOPP (p < 0.001), higher body mass index (BMI; p = 0.001), and higher waist to hip ratio (p = 0.001). Retinal thickness was not significantly associated with body composition parameters, including BMI and appendicular lean mass adjusted with squared height. Higher MOPP was significantly correlated with lower IOP (p < 0.001), higher BMI (p < 0.001), higher waist to hip ratio (p < 0.001), and higher appendicular lean mass divided by squared height (p = 0.009).
Conclusions
Skeletal muscle mass and BMI were significantly associated with MOPP. Since low MOPP is a known risk factor for glaucoma, its association with skeletal muscle mass may indicate a relationship between systemic muscle health, ocular blood perfusion, and glaucomatous damage. Further large-scale studies are needed to validate these associations between skeletal muscle mass and glaucoma and explore their clinical implications. |
| Key Words:
Body mass index, Glaucoma, Optical coherence tomography, Perfusion, Skeletal muscle |
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