Comments on “The Correlation of Peripapillary and Juxtapapillary Choroidal Thickness in Healthy Subjects”

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Korean J Ophthalmol. 2023;37(2):198-199
1Stanford University School of Medicine, Stanford, CA, USA
2Ankara Sehir Hastanesi, Ankara, Turkey
Corresponding Author: Salih Uzun E-mail:
Received 2022 September 08; Accepted 2023 February 21.

Dear Editor,

We have read and reviewed the article entitled “The correlation of peripapillary and juxtapapillary choroidal thickness in healthy subjects” by Son et al. [1] with great interest. The authors investigated the peripapillary choroidal thickness (PPCT) and juxtapapillary choroidal thickness (JPCT) by using circle and radial B-scan images, respectively. The authors showed that the two measures of choroidal thickness (CT) around the optic nerve head were well correlated. However, the peripapillary choroid was generally thicker than the juxtapapillary choroid, especially in eyes with small Bruch’s membrane opening area. We congratulate the authors for their precious study, and we would like to request more details and their valuable contributions to the article.

The choroid is one of the most vascularized regions of the human body. Therefore, various local and systemic physiologic/pathologic conditions and environmental factors have effects on CT. It has been shown in the literature that age, sex, systemic or local diseases and their treatments, use of medicine, intraocular pressure, refractive error, axial length of the globe, and many other factors have effects on CT [2]. In addition, pregnancy, body mass index, menstrual cycle, and systemic blood pressure have a remarkable effect on CT. Furthermore, consuming food, and caffeinated or noncaffeinated drinks, and exercise before optical coherence tomography measurements can cause significant changes in CT [2]. Moreover, CT shows considerable diurnal variation and is able to increase by 50% in an hour and by four times in a few days [3]. We would like to ask authors whether all those factors have been assessed in the study.




Conflicts of Interest: None.

Funding: None.


1. Son DH, Lee J, Kim JA. The correlation of peripapillary and juxtapapillary choroidal thickness in healthy subjects. Korean J Ophthalmol 2022;36:379–89.
2. Tan KA, Gupta P, Agarwal A, et al. State of science: choroidal thickness and systemic health. Surv Ophthalmol 2016;61:566–81.
3. Nickla DL, Wallman J. The multifunctional choroid. Prog Retin Eye Res 2010;29:144–68.

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