Relapsed Disciform Stromal Herpetic Keratitis and mRNA COVID-19 Vaccination

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Korean J Ophthalmol. 2022;36(2):176-177
Publication date (electronic) : 2022 April 4
doi :
1Private Academic Consultant, Bangkok, Thailand
2Honorary Professor, Department of Community Medicine, Dr DY Patil University, Pune, India
Received 2021 December 23; Accepted 2022 February 18.

Dear Editor,

We would like to share ideas on “Relapsed disciform stromal herpetic keratitis following mRNA COVID-19 vaccination [1].” We agree that the patient has relapsed disciform stromal herpetic keratitis. However, a causal interrelationship with coronavirus disease 2019 (COVID-19) vaccination remains an issue for fur ther studies. COVID-19 vaccine might cause ocular adverse effects and herpetic keratitis might be a clinical problem following COVID-19 vaccination. Basically, immunological abnormality induced by vaccine might be a trigger factor for this adverse event. However, no data on abnormal immune parameter is available for finalized conclusion. For an eye complication after COVID-19 vaccination, it might be due to immunepathology, coincidence, or other pathophysiological process [2]. For a case with possibility of herpetic reactivation, other lesions at patients might also occur and it is useful to have a complete body examination of the patient. Finally, a medical disorder might concurrently occur after COVID-19 vaccination. For example, dengue is reported in vaccine recipient [3] and stromal keratitis is also a possible rare clinical problem induced by dengue [4].




Conflicts of Interest





1. Song MY, Koh KM, Hwang KY, et al. Relapsed disciform stromal herpetic keratitis following mRNA COVID-19 vaccination. Korean J Ophthalmol 2021;36:80–2.
2. Mungmunpuntipantip R, Wiwanitkit V. Correspondence on “Acute corneal endothelial graft rejection following COVID-19 vaccination”. J Fr Ophtalmol 2022;45:e3.
3. Kebayoon A, Wiwanitkit V. Dengue after COVID-19 vaccination: possible and might be missed. Clin Appl Thromb Hemost 2021;27:10760296211047229.
4. Bawankar P, Lahane T, Parekh R, et al. An unusual occurrence of stromal keratitis in dengue fever. Indian J Ophthalmol 2018;66:1631–3.

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