Factors Associated with Macular Staphyloma Area on Ultra-widefield Fundus Images

Zhang, Xinmei; Pazo, Emmanuel Eric; Zhang, Aoqi; Yang, Lanting; Dai, Guangzheng; Wu, Xianwei; Xia, Yang; Meshi, Amit; He, Wei; Lin, Tiezhu

doi:.0..

Korean J Ophthalmol > Epub ahead of print

Original Article

DOI: https://doi.org/10.3341/kjo.2021.0081 [Epub ahead of print]
Published online January 24, 2022.

Factors Associated with Macular Staphyloma Area on Ultra-widefield Fundus Images

Xinmei Zhang^1,2, Emmanuel Eric Pazo¹, Aoqi Zhang^1,2, Lanting Yang^1,2, Guangzheng Dai¹, Xianwei Wu¹, Yang Xia¹, Amit Meshi³, Wei He¹, Tiezhu Lin^1,4

¹Department of Ophthalmology, He Eye Specialist Hospital, Shenyang 110000, Liaoning Province, China
²Department of Ophthalmology, Dalian Medical University, Dalian 116000, Liaoning Province, China
³Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6100000, Israel
⁴Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China

Correspondence: Tiezhu Lin, Tel: +86-13654032699,
Email: 360970814@qq.com

Received: 1 June 2021 • Revised: 29 September 2021 • Accepted: 6 January 2021

Abstract

Purpose
To assess the feasibility of applying ultra-widefield fundus (UWF) images for macular staphyloma area (MSA) measurement, and investigate the associated factors with MSA.
Methods
This is a retrospective study. MSA was measured by UWF imaging. Central foveal thickness (CFT), subfoveal choroidal thickness (SFCT), subfoveal scleral thickness (SFST) were measured on spectral-domain optical coherence tomography. Intraclass correlation coefficients (ICC) of MSA measurement would be evaluated. Multiple linear regression analysis was used to analyse the associated factors with MSA.
Result
s: In total 135 eyes of 92 patients were enrolled. The mean age was 64.73±10.84 years. Mean MSA on UWF image was 279.67±71.70 mm2. Intraclass correlation coefficients (ICC) of MSA measurement was 0.965 (95% confidence interval (CI), 0.946-0.977; p<0.001). In the multiple linear regression analysis, after adjusting for SFCT, BCVA, CFT, SFST, the factors independently related to MSA were axial length (AL) (β=8.352; 95% CI, 3.306-13.398; p=0.001), sex (β=-26.673; 95% CI, -51.759--1.586; p=0.037), age (β=1.184; 95% CI, 0.020-2.348; p=0.046).
Conclusions
It is feasible to measure MSA on UWF image. Female, longer AL, older age may indicate larger area of macular staphyloma.

Key Words: staphyloma; macular staphyloma; ultra-widefield fundus images; measurement; area