Korean J Ophthalmol > Epub ahead of print
DOI: https://doi.org/10.3341/kjo.2021.0081    [Epub ahead of print]
Published online January 24, 2022.
Factors Associated with Macular Staphyloma Area on Ultra-widefield Fundus Images
Xinmei Zhang1,2, Emmanuel Eric Pazo1, Aoqi Zhang1,2, Lanting Yang1,2, Guangzheng Dai1, Xianwei Wu1, Yang Xia1, Amit Meshi3, Wei He1, Tiezhu Lin1,4
1Department of Ophthalmology, He Eye Specialist Hospital, Shenyang 110000, Liaoning Province, China
2Department of Ophthalmology, Dalian Medical University, Dalian 116000, Liaoning Province, China
3Department of Ophthalmology, Rabin Medical Center, Petah Tikva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6100000, Israel
4Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Correspondence:  Tiezhu Lin, Tel: +86-13654032699, 
Email: 360970814@qq.com
Received: 1 June 2021   • Revised: 29 September 2021   • Accepted: 6 January 2021
Abstract
Purpose
To assess the feasibility of applying ultra-widefield fundus (UWF) images for macular staphyloma area (MSA) measurement, and investigate the associated factors with MSA.
Methods
This is a retrospective study. MSA was measured by UWF imaging. Central foveal thickness (CFT), subfoveal choroidal thickness (SFCT), subfoveal scleral thickness (SFST) were measured on spectral-domain optical coherence tomography. Intraclass correlation coefficients (ICC) of MSA measurement would be evaluated. Multiple linear regression analysis was used to analyse the associated factors with MSA.
Result
s: In total 135 eyes of 92 patients were enrolled. The mean age was 64.73±10.84 years. Mean MSA on UWF image was 279.67±71.70 mm2. Intraclass correlation coefficients (ICC) of MSA measurement was 0.965 (95% confidence interval (CI), 0.946-0.977; p<0.001). In the multiple linear regression analysis, after adjusting for SFCT, BCVA, CFT, SFST, the factors independently related to MSA were axial length (AL) (β=8.352; 95% CI, 3.306-13.398; p=0.001), sex (β=-26.673; 95% CI, -51.759--1.586; p=0.037), age (β=1.184; 95% CI, 0.020-2.348; p=0.046).
Conclusions
It is feasible to measure MSA on UWF image. Female, longer AL, older age may indicate larger area of macular staphyloma.
Key Words: staphyloma; macular staphyloma; ultra-widefield fundus images; measurement; area


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