Prostaglandin E in rabbit aqueous humor after Nd-YAG laser photodisruption of the iris and the effect of topical indomethacin pretreatment.

Joo,  Chun Ki; Kim,  Man Soo; Kim,  Jae Ho

doi:1987.1.2.122

Korean J Ophthalmol > Volume 1(2); 1987 > Article

Research Support, Non-U.S. Gov't

Korean Journal of Ophthalmology 1987;1(2):122-127.
DOI: https://doi.org/10.3341/kjo.1987.1.2.122 Published online December 30, 1987.

Prostaglandin E in rabbit aqueous humor after Nd-YAG laser photodisruption of the iris and the effect of topical indomethacin pretreatment.

Chun Ki Joo, Man Soo Kim, Jae Ho Kim

Department of Ophthalmology, Kangnam St. Mary's Hospital, Catholic University Medical College, Seoul, Korea.

Abstract

Rabbit eyes were irradiated with a neodymium-yttrium-aluminum-garnet (Nd-YAG) laser and the changes in prostaglandin E and protein levels in the aqueous humor were measured. Intraocular pressure and pupil diameter were also determined in the same rabbits. Prostaglandin E and protein in the aqueous humor were increased depending upon the number of laser lesions. The increase in intraorular pressure and the decrease in pupil diameter occurred at similar dosages of laser irradiation. The response of the iris to the photodisruption was rapid. Changes in prostaglandin and protein contents and pupil diameter were already prominent 15 min after laser irradiation. Indomethacin pretreatment abolished most of these responses, suggesting that acute reactions following photodisruption were largely dependent on prostaglandin synthesis in iris tissue

Key Words: Nd-YAG laser;blood-aqueous barrier;photodisruption;prostaglandin;indomethacin;miosis