Positive family history of glaucoma is a risk factor for increased IOP rather than glaucomatous optic nerve damage (POAG vs OH vs normal control).

Uhm,  Ki Bang; Shin,  Dong H.

doi:1992.6.2.100

Korean J Ophthalmol > Volume 6(2); 1992 > Article

Comparative Study

Korean Journal of Ophthalmology 1992;6(2):100-104.
DOI: https://doi.org/10.3341/kjo.1992.6.2.100 Published online December 30, 1992.

Positive family history of glaucoma is a risk factor for increased IOP rather than glaucomatous optic nerve damage (POAG vs OH vs normal control).

Ki Bang Uhm, Dong H. Shin

¹Department of Ophthalmology, School of Medicine, Hanyang University, Seoul, Korea.
²Kresge Eye Institute, School of Medicine, Wayne State University, Detroit, Michigan, USA.

Abstract

To elucidate the family history of glaucoma (FHG) as a risk factor for ocular hypertension(OH) vs glaucomatous optic nerve damage, we reviewed the clinical records of 361 primary open-angle glaucoma(POAG) patients, 178 OH subjects, and 927 normal controls randomly selected from an urban medical center eye clinic. The prevalence of a positive FHG was 27% in the POAG patients, 47% in the OH subjects, and 11% in the normal controls. Whereas a positive FHG was a significant risk factor for both OH and glaucoma compared to normal control subjects (OR = 7.56, 95% CI: 5.27-10.85, P < .0001 for OH; OR = 3.15, 95% CI: 2.31-4.31, P < .0001), it was a risk factor more significantly for OH than for glaucoma being significantly more prevalent in OH than in POAG (OR = 2.40, 95% CI: 1.65-3.49, P < .0001). These results suggest the importance of additional risk factors other than IOP for glaucomatous optic nerve damage.

Key Words: family history of glaucoma;risk factors;primary open-angle glaucoma;ocular hypertension