Clinical evaluation of corneal diseases associated with floppy eyelid syndrome.

Lee,  Woo Jae; Kim,  Jae Chan; Shyn,  Kyung Hwan

doi:1996.10.2.116

Korean J Ophthalmol > Volume 10(2); 1996 > Article

Research Support, Non-U.S. Gov't

Korean Journal of Ophthalmology 1996;10(2):116-121.
DOI: https://doi.org/10.3341/kjo.1996.10.2.116 Published online December 30, 1996.

Clinical evaluation of corneal diseases associated with floppy eyelid syndrome.

Woo Jae Lee, Jae Chan Kim, Kyung Hwan Shyn

Department of Ophthalmology, Chung Ang University Medical Center, Seoul, Korea.

Abstract

We examined 18 cases of floppy eyelid syndrome, first reported in the Orient, in patients ranging in age from 11 to 55 years (mean 24 years); 16 were men and two were women. In contrast to previous reports in which almost all patients were obese men, only three of our patients were mildly obese. The most common abnormal corneal finding was punctate epithelial keratopathy (five patients-28%). Keratoconus was detectable in three patients (17%) overall; it was bilateral in one case and unilateral in two. Other miscellaneous corneal findings were corneal astigmatism and corneal opacity. In two cases, we found a familial tendency to skin hyperextensibility and joint hypermobility, and in one case, floppy eyelid syndrome developed after pars plana vitrectomy. The pathogenesis of the syndrome is still unknown, but our findings suggest that the more important pathogenetic risk factors are not obesity and sleeping pattern, but genetic collagen and/or elastin abnormality.

Key Words: floppy eyelid syndrome;papillary conjunctivitis;keratoconus;corneal astigmatism;corneal opacity