We read the article entitled "Macular choroidal thickness and volume measured by swept-source optical coherence tomography in healthy Korean children" by Lee et al. [1] with great interest. The authors measured the thickness and volume of the choroid in healthy Korean children using optical coherence tomography. They examined 80 eyes of 40 healthy children and teenagers (<18 years), and compared them with 44 eyes of 35 healthy adults (≥18 years). The authors discovered that overall macular choroidal thickness (CT) and volume were significantly greater in children and teenagers compared to adults. The pediatric subfoveal choroid was prone to thinning with increasing age, axial length, and refractive error. We congratulate the authors for their study on macular CT and volume in children and we would like to request more details and their contribution to the article.

CT is affected by many local and systemic pathologic/physiologic conditions including diurnal variation, axial length, refractive factor, intraocular pressure, systemic or local diseases and their treatments, and drug use as mentioned in the study [2,3,4]. However, we would like to ask to the authors if other factors such as smoking, alcohol consumption, exercising, sleeping conditions, caffeinated/non-caffeinated drink consumption, systemic blood pressure, and body mass index of patients and standardized environmental lighting have been taken into consideration.

Also, gender status within the two groups of children and adults was not disclosed. Although effect of gender on CT was mentioned in the study, we are especially curious if the parameters which apparently affect CT such as menstrual cycle and pregnancy were considered [2]. In conclusion, designing studies to better examine CT can increase the reliability of data obtained and statistical assessments.